Наступне засідання англомовного гуртка «Talk Biology» відбудеться 20 вересня 2023 р. о 16:00 дистанційно, з використанням онлайн-платформи Zoom

 Тема: «Armed and Dangerous: Natural toxins and alkaloids targeting ion channels»

Посилання для підключення:
https://knu-ua.zoom.us/j/87027087543?pwd=bG5aRXQ1Y1ZBd2pseWdlOHpVZ2ZiZz09 
Ідентифікатор конференції: 870 2708 7543
Код доступу: 293298

Завідувач кафедри біофізики та медичної інформатики
Олександр ЖОЛОС

Доцент кафедри іноземних мов природничих факультетів
Юлія БАБЧУК

Детальніше:

Thousands of animal and plant species have evolved to produce various toxins and alkaloids designed either to defend themselves or attack and kill their prey. Many of these compounds are deadly, while others cause some highly unpleasant conditions and symptoms, such as pain, inflammation, itch, nausea, vomiting etc. During millions of years of evolution these molecules have been “polished” to become highly potent and selective – a yet to be achieved dream of the pharmaceutical research and development. In many cases, voltage- and ligand-gated ion channels represent the molecular targets of these natural compounds highlighting multiple vital roles of ion channels. We will discuss the usefulness of natural toxins as pharmacological tools for the study of ion channels, characterization of their biological functions, as well as an important source of major medications, including first-in-class agents, for the treatment of many diseases from cardiovascular and metabolic disorders to chronic pain.

Further readings:

1. Zholos A.V., Dryn D.O., Melnyk M.I. (2023). General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRPC channels and visceral nociception. Frontiers in Physiology 14:1174655
2. Zholos A.V., Moroz O.F., Storozhuk M.V. (2019). Curcuminoids and novel opportunities for the treatment of Alzheimer's disease: which molecules are actually effective? Current Molecular Pharmacology 12 (1), 12-26.
3. Korogod S.M., Tsagareli M., Delmas P., Zholos A.V. (2022). Temperature-dependent mechanisms of neuron functioning: Emerging concepts. Frontiers in Cellular Neuroscience 16:1009071.
4. Siemens J, Hanack C (2014). Modulation of TRP ion channels by venomous toxins. Handb Exp Pharmacol 223,1119-1142.
5. Arias HR (2006). Marine toxins targeting ion channels. Mar Drugs 4, 37-69.
6. Zhang S, Gao B, Zhu S (2015). Target-driven evolution of scorpion toxins. Sci Rep 5, 14973.
7. Sousa SR, Vetter I, Lewis RJ (2013). Venom peptides as a rich source of Cav2.2 channel blockers. Toxins 5, 286-314.